Prostaglandin Metabolism

Prostaglandin metabolism and intraocular pressure.

The plasma lipid alterations characteristic of essential fatty acid deficiency (EFAD) generally appear one to two weeks after the initiation of fat free parenteral nutritional (PN), and may be associated with a reduction in prostaglandin (PG) formation. In the present study the relationship between exclusion of fat from the diet and changes in intraocular pressure (IOP) and PGE2 plasma levels w...

Oxidative metabolism of diethylstilbestrol by prostaglandin synthetase.

The cooxidative metabolism of the transplacental carcinogen, diethylstilbestrol (DES), was examined using ram seminal vesicle microsomes. The major extractable metabolite was beta-dienestrol (Z,Z-DIES) and represented about 35% of the added DES in 3-min incubations supplemented with arachidonic acid. Its formation was dependent upon the presence of arachidonic acid, whereas reduced nicotinamide...

Metabolism of Prostacyclin and 6-Keto-prostaglandin

Labeled and unlabeled prostacyclin and 6-keto-PGF1, were infused into healthy volunteers; urine was chromatographed on different systems including high pressure liquid chromatography. The peaks obtained by the latter method were derivatized to the methoxime methyl ester trimethyl silyl ether and analyzed by gasliquid chromatography-mass spectrometry. After infusion of prostacyclin the follo...

Prostaglandin and norepinephrine metabolism: effect of indomethacin on prostaglandin synthesis and norepinephrine turnover rate.

Metabolism of prostaglandin glycerol esters and prostaglandin ethanolamides in vitro and in vivo.

Prostaglandin glycerol esters (PG-Gs) and prostaglandin ethanolamides (PG-EAs) are generated by the action of cyclooxygenase-2 on the endocannabinoids 2-arachidonylglycerol (2-AG) and arachidonylethanolamide, respectively. These novel eicosanoids may have unique pharmacological properties and/or serve as latent sources of prostaglandins at sites remote from their tissue of origin. Therefore, we...